Inducing Flow Instabilities in Aneurysm Geometries via the Reynolds-Orr Method

Abstract Ruptured intracranial aneurysms are the leading cause of hemorrhagic strokes. Although prevalent in as much 4% adult population, most do not rupture, and their growth risk rupture remains difficult to predict. Previous studies have identified abnormal wall shear stress patterns blood pressure spikes, both features unstable flows, key factors aneurysm behavior. While computational fluid dynamics has been enlisted help study no consensus established on how impose flow conditions. Here, we use Reynolds-Orr instability analysis calculate perturbations that capable inducing 3D arterial geometries with without aneurysms. These lay foundation for future by providing mathematically consistent conditions time-dependent Navier-Stokes simulations.